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        閲戞弧璐僵绁ㄥ張鏈変笁椤圭鎶鍙戞槑鎻借幏鍥介檯涓撳埄

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        銆銆鎹簡瑙o紝鈥滅~閰告櫤鑳藉噣鍖栧洖鏀惰缃濈郴鍒╃敤璺濈浼犳劅鍣ㄥ鍥哄畾鏉夸笌婊戝姩婊ゆ按鏉夸箣闂寸殑璺濈杩涜妫娴嬶紝浠庤屼娇寰楁帶鍒跺櫒鍦ㄥ浐瀹氭潅璐ㄦ尋鍘嬪厖鍒嗗悗鎺у埗鎺у埗闂ㄦ墦寮锛屽鍥哄畾鏉傝川杩涜鏀堕泦锛屾湁鍒╀簬鍑忓皯搴熸恫涓浐浣撴潅璐ㄧ殑鍚噺锛屽埄鐢ㄧ紦鍐插脊绨у浜岀骇闄ゆ潅绠辫繘琛岀紦鍐诧紝寤堕暱浜岀骇闄ゆ潅绠变笌杞姩杞寸殑浣跨敤瀵垮懡銆傛湰鍙戞槑鍙纭吀搴熸恫杩涜鏅鸿兘鍖栧閲嶉櫎鏉傦紝鍒╃敤闄ゆ潅妯″潡鎻愰珮鍥烘恫鍒嗙鐨勬晥鐜囷紝渚夸簬鍥轰綋鏉傝川鐨勬竻鐞嗐傗滈晙闀嶅簾姘存櫤鑳藉噣鍖栬缃濈郴閫氳繃搴熸按澶勭悊妯″潡鍜屽噣鍖栧鐞嗗崟鍏冪浉閰嶅悎锛屾寔缁笉鏂湴瀵瑰簾姘磋繘琛屽噣鍖栵紝涓斾繚璇佸簾姘村叿鏈夊厖瓒冲鐞嗘椂闂寸殑鍚屾椂涓嶅奖鍝嶅鐞嗘晥鐜囷紝閫氳繃涓ゆ鍑鍖栵紝瀹炵幇姘磋川褰诲簳鍑鍖栵紱鍚屾椂閫氳繃婊戝潡甯﹀姩寮规у惛闄勮啘鎶栧姩锛屼粠鑰屼竴鏂归潰閬垮厤鏉傝川鍚搁檮锛屽彟涓鏂归潰澧炲己搴熸按娴佸姩锛屾彁楂樺鐞嗘晥鐜囥傗滅敤绔嬫柟Ia3d缁撴瀯浠嬪瓟纰矯MK-8鐩存帴鐢靛寲瀛︿紶鎰熷櫒娴嬪畾鐥曢噺鍗″反姘х殑鏂规硶鈥 绯婚噰鐢ㄧ珛鏂笽a3d缁撴瀯浠嬪瓟纰矯MK-8淇グ鐜荤⒊鐢垫瀬锛屽皢鎵鏋勫缓鐨勪紶鎰熷櫒鐢ㄤ簬鍗″反姘х殑鐩存帴娴嬪畾锛屽綋鍗″反姘у湪0.5nM~500.0 nM娴撳害鑼冨洿鍐呮椂锛岀數鍖栧淇″彿鍝嶅簲涓庡崱宸存哀鐨勬祿搴﹀憟鑹ソ鐨勭嚎鎬у叧绯伙紝鏂规硶妫鍑洪檺涓74.4 pM銆傛湰鍙戞槑鏄捐憲鎻愰珮浜嗗崱宸存哀妫娴嬬殑鐏垫晱搴︼紝瀵逛簬浣庢祿搴﹀崱宸存哀鐨勬娴嬫槗浜庤嚜鍔ㄥ寲銆

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